RESEARCH
We are investigating the interactions between human genetic alterations with microorganism mutations that help patients to prognosis or treatment. Namely, we focus on liver patients infected hepatitis B/C virus to find out how the virus mutations effect on cancer development. Genetic variants also have been mentioned that it influenced on patients to response with treatment, but the mechanism still unclear. The mutations statistic of large amount patients will help to answer. Moreover, the antibiotic resistance becomes more seriously that decreased efficiency treatment. Through the surveillance of resistance rates, our advice may help to reduce.
Recent and ongoing research projects:
· Identifying antibiotic resistance and CYP2C19 genotype of patients infected by Helicobacter Pylori and failed with treatment.
· Determining Hepatitis C virus core mutation and IL28B genotype of unresponsively treated patients.
· Applying qRT-PCR to detect Tyrosine Hydroxylase amplification on Neuroblastoma patients.
· Using next generation sequencing for early detection of aneuploidy by cell- free fetal DNA (cffDNA) in maternal blood. It is the new direction and applied in developed countries because of high sensitive and specificity and non-invasive procedure
· Studying some protein biomarkers as Glypican-3, GP-73 in the serum of HCC patients and HBV gene mutation profile on the PreS, X, Precore or Base Core promoter (BCP) regions to predict the risk of HCC in patients with chronic hepatitis B.