University of Medicine and Pharmacy, HCMC

Center for Molecular Biomedicine

PUBLICATIONS


 

1. Hoai-Nghia Nguyen and Jeffrey A Hadwiger. The Gα4 G protein subunit interacts with the MAP kinase ERK2 using a D-motif that regulates developmental morphogenesis in Dictyostelium. Dev Bio. 2009 Nov 15; 335(2): 385-95. 


2. Brent Raisley, Hoai-Nghia Nguyen and Jeffrey A Hadwiger. Gα5 subunit-mediated signaling requires a Dmotif and the MAP kinase ERK1 in Dictyostelium. Microbiology. 2010, 156; 789-797 


3. Hoai-Nghia Nguyen, Brent Raisley and Jeffrey A Hadwiger. MAP kinases have different functions in Dictyostelium G protein-mediated signaling. Cell Signal. 2010 May, 22 (5): 836-847 

4. Jeffrey A Hadwiger and Hoai-Nghia Nguyen. MAPKs in development: insights from Dictyostelium signaling pathways. Biomol Concepts. 2011 April, 2(2): 39-46 

5. Schwebs DJ, Nguyen HN, Miller JA, Hadwiger JA. Loss of cAMP-specific phosphodiesterase rescues spore development in G protein mutant in dictyostelium. Cell Signal. 2014 Feb, 26(2): 409-418 

6. Nguyen HN, Afkari Y, Senoo H, Sesaki H, Devreotes PN, Iijima M. Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene. 2013 Dec. 

7. Hoai-Nghia Nguyen, Jr-Ming Yang, Yashar Afkari, Ben Ho Park, Hiromi Sesaki, Peter N. Devreotes, and Miho Iijima. ePTEN: an Enhanced PTEN with Increased Tumor Suppressor Activities. Proc. Natl. Acad. Sci. U.S.A. June 16, 2014. 

8. Hoai-Nghia Nguyen, Jr-Ming Yang, Ben Ho Park, Hiromi Sesaki, Peter N. Devreotes, and Miho Iijima. A New Class of Cancer-Associated PTEN Mutations Defined by Membrane Translocation Defects. Oncogene. 2015 Jul;34(28):3737-43. 

9. Jr-Ming Yang, Hoai-Nghia Nguyen, Hiromi Sesaki, Peter N. Devreotes, and Miho Iijima. Engineering PTEN function: membrane association and activity. Methods. 2015 May;77-78:119-24. 

10. Nguyen HN, Yang JM, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, Iijima M. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN. Sci Rep. 2015 Jul 28. 

11. Jr-Ming Yang*, Paula Schiapparelli*, Hoai-Nghia Nguyen*, Qiang Zhang, Sara Abbadi, Mario Amzel, Hiromi Sesaki, Alfredo Quinones-Hinojosa, Miho Iijima. Mono-ubiquitination of PTEN Promotes Protein Stability and Nuclear Localization in Primary Brain Cancer. Oncogene (In press). (* these authors have equal contribution) 

12. Yong ST, Nguyen HN, Choi JH, Bortner CD, Williams J, Pulloor NK, Krishnan MN, Shears SB. Identification of a functional nuclear translocation sequence in hPPIP5K2. BMC Cell Biol. 2015 Jun 18. 

13. Chunfang Gu, Hoai-Nghia Nguyen, Alexandre Hofer, Henning J. Jessen, Xuming Daic, Huanchen Wang, Stephen B. Shears. The Significance of the Bifunctional Kinase/Phosphatase Activities of PPIP5Ks for Coupling Inositol Pyrophosphate Cell-Signaling to Cellular Phosphate Homeostasis. Journal of Biological Chemistry. 2017 Jan 26. pii: jbc.M116.765743. doi: 10.1074/jbc.M116.765743 

14. Hoai-Nghia Nguyen, Chunfang Gu, Douglas Ganini da Silva, Henning J. Jesson, Zhen Gu, Huanchen Wang, Stephen B. Shears. Knockout of 5-InsP7 Kinase Activity Transforms the HCT116 Tumor Cell line into a Hypermetabolic, Senescent-Like Phenotype. Proc. Natl. Acad. Sci. U.S.A. (submitted) 

15. Wang H*, Nguyen HN*, Chunfang G, Fitzgerald MC, Shears SB. A novel role of inositol pyrophosphate InsP8 in MYC-driven metabolic reprogramming. (prepared) (* these authors have equal contribution)